Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 6, Pages 10136-10149Publisher
MDPI
DOI: 10.3390/ijms150610136
Keywords
soft coral; pregnane; Scleronephthya flexilis; cytotoxicity; MOLT-4
Funding
- National Dong Hwa University
- National Museum of Marine Biology and Aquarium
- Asia-Pacific Ocean Research Center, National Sun Yat-sen University
- Ministry of Science and Technology [NSC 102-2325-B-291-001, 101-2320-B-291-001-MY3]
- CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan
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Three pregnane-type steroids, including a new metabolite, 3 beta-methoxy-5,20-pregnadiene (1) along with two known analogues, 3 beta-acetoxy-5,20-pregnadiene (2) and 5 alpha-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
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