Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 2, Pages 2087-2118Publisher
MDPI
DOI: 10.3390/ijms15022087
Keywords
chemoenzymatic synthesis; enzyme mimics; zinc; asymmetric synthesis; cofactor regeneration
Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [18390009, 19659026, 22390005, 22659005, 24659058]
- High-Tech Research Center Project for Private Universities
- MEXT
- Grants-in-Aid for Scientific Research [22659005, 24659058] Funding Source: KAKEN
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Extending carbon frameworks via a series of C-C bond forming reactions is essential for the synthesis of natural products, pharmaceutically active compounds, active agrochemical ingredients, and a variety of functional materials. The application of stereoselective C-C bond forming reactions to the one-pot synthesis of biorelevant compounds is now emerging as a challenging and powerful strategy for improving the efficiency of a chemical reaction, in which some of the reactants are subjected to successive chemical reactions in just one reactor. However, organic reactions are generally conducted in organic solvents, as many organic molecules, reagents, and intermediates are not stable or soluble in water. In contrast, enzymatic reactions in living systems proceed in aqueous solvents, as most of enzymes generally function only within a narrow range of temperature and pH and are not so stable in less polar organic environments, which makes it difficult to conduct chemoenzymatic reactions in organic solvents. In this review, we describe the design and synthesis of chiral metal complexes with Zn2+ ions as a catalytic factor that mimic aldolases in stereoselective C-C bond forming reactions, especially for enantioselective aldol reactions. Their application to chemoenzymatic reactions in aqueous solution is also presented.
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