Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 12, Pages 21865-21874Publisher
MDPI AG
DOI: 10.3390/ijms151221865
Keywords
Cladiella krempfi; eunicellin-based diterpenoid; anti-inflammatory activity
Funding
- National Science Council of Taiwan [NSC 102-2113-M-110-001-MY2]
- Aim for the Top University Program from Ministry of Education of Taiwan [03C030205]
- National Sun Yat-sen University-Kaohsiung Medical University Joint Project (NSYSU-KMU) [02C030117]
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Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported.
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