Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 9, Pages 16302-16319Publisher
MDPI
DOI: 10.3390/ijms150916302
Keywords
Mentha piperita; response surface methodology; polysaccharide; antitumor; antioxidant
Funding
- Open Research Fund Program of Key Laboratory of Marine Drugs (Ocean University of China)
- Ministry of Education [KLMD] [(OUC) 201304]
- National Natural Science Foundation of China [41306133, 31240030, 81202104]
- Development of new salt-tolerant plant cultivars and their integrated utilization [2011DFA30990]
- Excellent Middle-Aged and Youth Scientist Award Foundation of Shandong Province [BS2013HZ025, BS2013HZ016]
- National High Technology Research and Development Program of China (863 Program) [2013AA093001]
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This study describes the extraction, preliminary characterization and evaluation of the in vitro antitumor and antioxidant activities of polysaccharides extracted from Mentha piperita (MPP). The optimal parameters for the extraction of MPP were obtained by Box-Behnken experimental design and response surface methodology (RSM) at the ratio of water to raw material of 20, extraction time of 1.5 h and extraction temperature at 80 degrees C. Chemical composition analysis showed that MPP was mainly composed of glucuronic acid, galacturonic acid, glucose, galactose and arabinose, and the molecular weight of its two major fractions were estimated to be about 2.843 and 1.139 kDa, respectively. In vitro bioactivity experiments showed that MPP not only inhibited the growth of A549 cells but possessed potent inhibitory action against DNA topoisomerase I (topo I), and an appreciative antioxidant action as well. These results indicate that MPP may be useful for developing safe natural health products.
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