Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 2, Pages 3487-3499Publisher
MDPI
DOI: 10.3390/ijms14023487
Keywords
phospholipids; pre-eclampsia; placenta
Funding
- Swiss National Science Foundation [320030-119984, 31003A-130815]
- Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Switzerland
- SwissLife Jubilaumsstiftung
- Swiss National Science Foundation (SNF) [320030-119984, 31003A_130815] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Physiological pregnancy is associated with an increase in lipids from the first to the third trimester. This is a highly regulated response to satisfy energy and membrane demands of the developing fetus. Pregnancy disorders, such as pre-eclampsia, are associated with a dysregulation of lipid metabolism manifesting in increased maternal plasma lipid levels. In fetal placental tissue, only scarce information on the lipid profile is available, and data for gestational diseases are lacking. In the present study, we investigated the placental lipid content in control versus pre-eclamptic samples, with the focus on tissue phospholipid levels and composition. We found an increase in total phospholipid content as well as changes in individual phospholipid classes in pre-eclamptic placental tissues compared to controls. These alterations could be a source of placental pathological changes in pre-eclampsia, such as lipid peroxide insult or dysregulation of lipid transport across the syncytiotrophoblast.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available