Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 5, Pages 8924-8947Publisher
MDPI AG
DOI: 10.3390/ijms14058924
Keywords
oxidative stress; stroke; neuroprotection; cerebral ischemia; melatonin
Funding
- James and Esther King Foundation for Biomedical Research Program [1KG01-33966]
- NIH NINDS [RO1 1R01NS071956-01]
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The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
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