Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 4, Pages 6542-6555Publisher
MDPI
DOI: 10.3390/ijms14046542
Keywords
PGE(2); G-protein coupled receptors; EP2; EP4; dendritic cell
Funding
- HFSP young investigator grant
- Dutch government [FES0908]
- Netherlands Organisation for Scientific Research (NWO) [836.09.002]
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Many processes regulating immune responses are initiated by G-protein coupled receptors (GPCRs) and report biochemical changes in the microenvironment. Dendritic cells (DCs) are the most potent antigen-presenting cells and crucial for the regulation of innate and adaptive immune responses. The lipid mediator Prostaglandin E2 (PGE2) via four GPCR subtypes (EP1-4) critically regulates DC generation, maturation and migration. The role of PGE(2) signaling in DC biology was unraveled by the characterization of EP receptor subtype expression in DC progenitor cells and DCs, the identification of the signaling pathways initiated by these GPCR subtypes and the classification of DC responses to PGE(2) at different stages of differentiation. Here, we review the advances in PGE(2) signaling in DCs and describe the efforts still to be made to understand the spatio-temporal fine-tuning of PGE(2) responses by DCs.
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