Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 7, Pages 13447-13462Publisher
MDPI
DOI: 10.3390/ijms140713447
Keywords
RGD; tumor therapy; tissue engineering
Funding
- National Natural Science Foundation of China [21076053, 20906016]
- Technological Research and Development Project of Hangzhou [20120232B13]
- China Postdoctoral Science Foundation [2012M521198]
- Natural Science Foundation of Zhejiang Province [LY13B060008]
- Program for Changjiang Scholars and Innovative Research Team in Chinese University [IRT1231]
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Arginine-Glycine-Aspartic (RGD), is the specific recognition site of integrins with theirs ligands, and regulates cell-cell and cell-extracellular matrix interactions. The RGD motif can be combined with integrins overexpressed on the tumor neovasculature and tumor cells with a certain affinity, becoming the new target for imaging agents, and drugs, and gene delivery for tumor treatment. Further, RGD as a biomimetic peptide can also promote cell adherence to the matrix, prevent cell apoptosis and accelerate new tissue regeneration. Functionalizing material surfaces with RGD can improve cell/biomaterial interactions, which facilitates the generation of tissue-engineered constructs. This paper reviews the main functions and advantages of RGD, describes the applications of RGD in imaging agents, drugs, gene delivery for tumor therapy, and highlights the role of RGD in promoting the development of tissue engineering (bone regeneration, cornea repair, artificial neovascularization) in recent years.
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