Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 2, Pages 4030-4049Publisher
MDPI AG
DOI: 10.3390/ijms14024030
Keywords
F-box; SCF complex; virus-host interactions; viral infection
Funding
- Brazilian Government Agency CNPq [482631/2010-4]
- International Foundation for Science [C/4978-1]
- CNPq
- Faperj
- CAPES
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The F-box domain is a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin-proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions.
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