Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 7, Pages 13391-13402Publisher
MDPI
DOI: 10.3390/ijms140713391
Keywords
cancer; nanomedicine; magnetic particles; doxorubicin; nanoparticles
Funding
- CYTORES GA CR [P301/10/0356 (EA 14)]
- CEITEC [CZ.1.05/1.1.00/02.0068]
- IGA [IP22/2013]
- MH CZ - DRO
- University Hospital Motol, Prague, Czech Republic [00064203]
- LPR
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Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
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