Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 3, Pages 5723-5733Publisher
MDPI
DOI: 10.3390/ijms14035723
Keywords
self-assembly; SAM of ssDNA; biomarker; 9G DNAChip; hybridization; C-reactive protein
Funding
- Hallym University Research Fund [HRF-201211-011]
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A 9G DNAChip obtained by allowing the formation of a self-assembled monolayer (SAM) of oligonucleotides appended with nine consecutive guanines on the chip surface has been applied in the detection of biomarkers. Using a 9G DNAChip, biomarker in the concentration range of 4 pg/mL to 40 fg/mL can be easily differentiated in the buffer matrix. Moreover, it is the first time that a biomarker with a concentration of 40 fg/mL has been detected in a mixture of proteins without use of any signal amplification technique.
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