Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 1, Pages 1566-1588Publisher
MDPI
DOI: 10.3390/ijms14011566
Keywords
RUNX1 (AML1); microRNAs (miRNAs); hematopoiesis; leukemia; transcription factor-microRNA circuits; gene regulatory networks
Funding
- NCI NIH HHS [P30 CA016056] Funding Source: Medline
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Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia.
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