Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 1, Pages 1207-1217Publisher
MDPI AG
DOI: 10.3390/ijms14011207
Keywords
molecularly imprinted polymer; MIP; morphology; BET; surface area; warfarin
Funding
- Swedish Research Council (VR)
- Knowledge Foundation (KKS)
- Carl Trygger Foundation
- Linnaeus University
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The relationship between molecularly imprinted polymer (MIP) morphology and template-rebinding over a series of warfarin-imprinted methacrylic acid co(ethylene dimethacrylate) polymers has been explored. Detailed investigations of the nature of template recognition revealed that an optimal template binding was obtained with polymers possessing a narrow population of pores (similar to 3-4 nm) in the mesopore size range. Importantly, the warfarin-polymer rebinding analyses suggest strategies for regulating ligand binding capacity and specificity through variation of the degree of cross-linking, where polymers prepared with a lower degree of cross-linking afford higher capacity though non-specific in character. In contrast, the co-existence of specific and non-specific binding was found in conjunction with higher degrees of cross-linking and resultant meso-and macropore size distributions.
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