4.7 Review

p53 and Ceramide as Collaborators in the Stress Response

Related references

Note: Only part of the references are listed.
Review Oncology

Targeting the ceramide system in cancer

Brian Henry et al.

CANCER LETTERS (2013)

Article Biochemistry & Molecular Biology

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

Meenu N. Perera et al.

BIOCHEMICAL JOURNAL (2012)

Article Biochemistry & Molecular Biology

Inactivation of ceramide transfer protein during pro-apoptotic stress by Golgi disassembly and caspase cleavage

Suchismita Chandran et al.

BIOCHEMICAL JOURNAL (2012)

Review Biochemistry & Molecular Biology

Ceramide synthases at the centre of sphingolipid metabolism and biology

Thomas D. Mullen et al.

BIOCHEMICAL JOURNAL (2012)

Article Biochemistry & Molecular Biology

Ceramide channels: Influence of molecular structure on channel formation in membranes

Meenu N. Perera et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

Article Biochemistry & Molecular Biology

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis

Elodie Lafont et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Biochemistry & Molecular Biology

DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells

Teka-Ann S. Haynes et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Biochemistry & Molecular Biology

Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts

Patricia Gangoiti et al.

BIOCHIMIE (2012)

Article Cell Biology

Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Anastasia R. Goloudina et al.

CELL CYCLE (2012)

Article Cell Biology

Cell surface ceramide controls translocation of transferrin receptor to clathrin-coated pits

Abo Bakr Abdel Shakor et al.

CELLULAR SIGNALLING (2012)

Article Biochemistry & Molecular Biology

Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis

Dan Gao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells

Jaleel Kizhakkayil et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content

Massimo Aureli et al.

GLYCOCONJUGATE JOURNAL (2012)

Article Biochemistry & Molecular Biology

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

Sharon Epstein et al.

JOURNAL OF LIPID RESEARCH (2012)

Article Biochemistry & Molecular Biology

Molecular simulation of rapid translocation of cholesterol, diacylglycerol, and ceramide in model raft and nonraft membranes

W. F. Drew Bennett et al.

JOURNAL OF LIPID RESEARCH (2012)

Article Biochemistry & Molecular Biology

Identification and characterization of protein phosphatase 2C activation by ceramide

David M. Perry et al.

JOURNAL OF LIPID RESEARCH (2012)

Article Medicine, Research & Experimental

Direct Induction of Apoptosis Using an Optimal Mitochondrially Targeted p53

Mohanad Mossalam et al.

MOLECULAR PHARMACEUTICS (2012)

Article Cell Biology

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

E. Aflaki et al.

CELL DEATH & DISEASE (2012)

Article Biochemistry & Molecular Biology

Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells

Lulu Jiang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Cell Biology

Ceramide triggers metacaspase-independent mitochondrial cell death in yeast

Didac Carmona-Gutierrez et al.

CELL CYCLE (2011)

Review Cell Biology

Ceramide kinase: The first decade

Frederic Bornancin

CELLULAR SIGNALLING (2011)

Editorial Material Cardiac & Cardiovascular Systems

p53-Upregulated Modulator of Apoptosis (PUMA) A Novel Proapoptotic Molecule in the Failing Heart

S. Elissa Altin et al.

CIRCULATION (2011)

Article Gastroenterology & Hepatology

p53 and PUMA Independently Regulate Apoptosis of Intestinal Epithelial Cells in Patients and Mice With Colitis

Ramanarao Dirisina et al.

GASTROENTEROLOGY (2011)

Article Biochemistry & Molecular Biology

Tethering Function of the Caspase Cleavage Fragment of Golgi Protein p115 Promotes Apoptosis via a p53-dependent Pathway

Poh Choo How et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis

Sergei A. Novgorodov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

Thomas D. Mullen et al.

JOURNAL OF LIPID RESEARCH (2011)

Article Biochemistry & Molecular Biology

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

Celine Charvet et al.

MOLECULAR CELL (2011)

Article Medicine, Research & Experimental

Prohibitin (PHB) acts as a potent survival factor against ceramide induced apoptosis in rat granulosa cells

Indrajit Chowdhury et al.

LIFE SCIENCES (2011)

Article Biochemistry & Molecular Biology

C6-Ceramide Enhances Phagocytic Activity of Kupffer Cells through the Production of Endogenous Ceramides

Jong Min Choi et al.

MOLECULES AND CELLS (2011)

Article Medicine, Research & Experimental

p53 Facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response

Gang Song et al.

MEDICAL HYPOTHESES (2011)

Article Medicine, General & Internal

Apoptosis and Expression of the Bcl-2 Family of Proteins and P53 in Human Pancreatic Ductal Adenocarcinoma

Dong Chen et al.

MEDICAL PRINCIPLES AND PRACTICE (2011)

Article Multidisciplinary Sciences

Mitochondrial Dysfunction Links Ceramide Activated HRK Expression and Cell Death

Farhan Rizvi et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

Hyunmi Lee et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

The Targeting of Plasmalemmal Ceramide to Mitochondria during Apoptosis

Eduard B. Babiychuk et al.

PLOS ONE (2011)

Article Pharmacology & Pharmacy

(R)-alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria

Jeffrey S. Monette et al.

PHARMACOLOGICAL RESEARCH (2011)

Article Developmental Biology

Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes

Dorit Kalo et al.

REPRODUCTION FERTILITY AND DEVELOPMENT (2011)

Review Biochemistry & Molecular Biology

Apoptotic Sphingolipid Ceramide in Cancer Therapy

Wei-Ching Huang et al.

JOURNAL OF LIPIDS (2011)

Article Biochemistry & Molecular Biology

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

Vidyaramanan Ganesan et al.

APOPTOSIS (2010)

Article Biochemistry & Molecular Biology

Ceramide-activated protein kinases A an C zeta inhibit kidney proximal tubule cell Na+-ATPase

Lindsey M. P. Cabral et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Article Biochemistry & Molecular Biology

Increased ceramide accumulation correlates with downregulation of the autophagy protein ATG-7 in MCF-7 cells sensitized to photodamage

Duska Separovic et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Article Biochemistry & Molecular Biology

Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis

Sang Kyu Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Pharmacology & Pharmacy

Metabolism of short-chain ceramide by human cancer cells-Implications for therapeutic approaches

Jacqueline V. Chapman et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Article Biochemistry & Molecular Biology

Ceramide channels and their role in mitochondria-mediated apoptosis

Marco Colombini

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Article Biochemistry & Molecular Biology

Importance of cytochrome c redox state for ceramide-induced apoptosis of human mammary adenocarcinoma cells

Arti Parihar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)

Review Biochemistry & Molecular Biology

Apoptosis in yeast: triggers, pathways, subroutines

D. Carmona-Gutierrez et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Chemistry, Medicinal

Ceramide and Cerebroside from the Stem Bark of Ficus mucuso (Moraceae)

Jean Jules Kezetas Bankeu et al.

CHEMICAL & PHARMACEUTICAL BULLETIN (2010)

Article Pharmacology & Pharmacy

Targeting the p53 Pathway of Apoptosis

Joana D. Amaral et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

Review Biochemistry & Molecular Biology

Ceramide-rich platforms in transmembrane signaling

Branka Stancevic et al.

FEBS LETTERS (2010)

Review Biochemistry & Molecular Biology

Regulation of ceramide channels by Bcl-2 family proteins

Vidyaramanan Ganesan et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis

Rosa Puca et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Plant Sciences

Cameroonemide A: a new ceramide from Helichrysum cameroonense

Kakam Zanetsie Antoine et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2010)

Article Biochemistry & Molecular Biology

The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis

Leah J. Siskind et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

Phospholipase D modulation by ceramide in senescence

Lisa M. Webb et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2010)

Review Cell Biology

Transcription-independent p53 apoptosis: an alternative route to death

Daniel Speidel

TRENDS IN CELL BIOLOGY (2010)

Review Pharmacology & Pharmacy

Sphingolipids in inflammation: pathological implications and potential therapeutic targets

Graeme F. Nixon

BRITISH JOURNAL OF PHARMACOLOGY (2009)

Article Genetics & Heredity

p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

Laura M. McNamee et al.

GENETICS (2009)

Article Oncology

DIVERSITY AND COMPLEXITY OF CERAMIDE GENERATION AFTER EXPOSURE OF JURKAT LEUKEMIA CELLS TO IRRADIATION

Dominique Ardail et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)

Review Oncology

Awakening guardian angels: drugging the p53 pathway

Christopher J. Brown et al.

NATURE REVIEWS CANCER (2009)

Article Cell Biology

A dual role of p53 in the control of autophagy

Ezgi Tasdemir et al.

AUTOPHAGY (2008)

Article Cell Biology

Regulation of autophagy by cytoplasmic p53

Ezgi Tasdemir et al.

NATURE CELL BIOLOGY (2008)

Review Cell Biology

Transcriptional control of human p53-regulated genes

Todd Riley et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cell Biology

Lipid signalling in disease

Matthias P. Wymann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cell Biology

Principles of bioactive lipid signalling: lessons from sphingolipids

Yusuf A. Hannun et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Biochemistry & Molecular Biology

The p53 family and programmed cell death

E. C. Pietsch et al.

ONCOGENE (2008)

Article Biochemistry & Molecular Biology

Modulation of total ceramide and constituent ceramide species in the acutely and chronically hypoxic mouse heart at different ages

Lama Noureddine et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2008)

Article Biochemistry & Molecular Biology

De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation

Shoghag Panjarian et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2008)

Article Oncology

PPP1CA contributes to the senescence program induced by oncogenic Ras

Maria E. Castro et al.

CARCINOGENESIS (2008)

Article Biochemistry & Molecular Biology

Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins

Johnny Stiban et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation

Christopher L. Brooks et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Pathology

Recent advances in the immunobiology of ceramide

Saumya Pandey et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2007)

Review Physiology

Mitochondrial membrane permeabilization in cell death

Guido Kroemer et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Cardiac & Cardiovascular Systems

Ceramide attenuates hypoxic cell death via reactive oxygen species signaling

S Lecour et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

Regulation of the sphingolipid signaling pathways in the growing and hypoxic rat heart

M El Alwani et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2005)

Article Multidisciplinary Sciences

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

JE Chipuk et al.

SCIENCE (2005)

Review Biophysics

Mitochondrial ceramide and the induction of apoptosis

LJ Siskind

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2005)

Article Surgery

Role of ceramide in ischemic preconditioning

JH Cui et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2004)

Review Biochemistry & Molecular Biology

The complex life of simple sphingolipids

AH Futerman et al.

EMBO REPORTS (2004)

Article Biochemistry & Molecular Biology

Down-regulation of sphingosine kinase-1 by DNA damage - Dependence on proteases and p53

TA Taha et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Molecular machinery for non-vesicular trafficking of ceramide

K Hanada et al.

NATURE (2003)

Article Biochemistry & Molecular Biology

Human homologues of LAG1 reconstitute acyl-CoA-dependent ceramide synthesis in yeast

I Guillas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Pharmacology & Pharmacy

Intracellular signal transduction pathways activated by ceramide and its metabolites

PP Ruvolo

PHARMACOLOGICAL RESEARCH (2003)

Article Biochemistry & Molecular Biology

Acetylation of p53 inhibits its ubiquitination by Mdm2

MY Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind.

YA Hannun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum

MCS Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Cdk5 phosphorylates p53 and regulates its activity

JW Zhang et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

P53 mediates ceramide-induced apoptosis in SKN-SH cells

SS Kim et al.

ONCOGENE (2002)

Article Biochemistry & Molecular Biology

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53

WH Hoffman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

H Birbes et al.

FASEB JOURNAL (2001)

Article Biochemistry & Molecular Biology

Ceramide generation by two distinct pathways in tumor necrosis factor α-induced cell death

GS Dbaibo et al.

FEBS LETTERS (2001)

Article Biochemistry & Molecular Biology

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release

M Schuler et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

W Zundel et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)