Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 5, Pages 10307-10331Publisher
MDPI
DOI: 10.3390/ijms140510307
Keywords
cancer; biomarker; DNA methylation; miRNAs
Funding
- Program for Innovative Research Team in Zhejiang Province [2010R50046]
- Department of Health in Zhejiang Province [N20100555, 20120542]
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Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
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