Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 2, Pages 4317-4325Publisher
MDPI
DOI: 10.3390/ijms14024317
Keywords
diterpenoid; soft coral; Sinularia flexibilis
Funding
- National Science Council of Taiwan [NSC 98-2313-B-276-001-MY3, NSC 101-2313-B-276-002]
- Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital Research Fund [101-FI-DBS-IAC-R-003]
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Chemical examination of the Taiwanese soft coral Sinularia flexibilis led to the isolation of five cembrane-based diterpenoids 1-5, including two new metabolites, 11-acetylsinuflexolide (1) and 11-acetyldihydrosinuflexolide (2). The structures of the new metabolites were determined based on extensive spectroscopic analysis, particularly mass spectrometry and 2D NMR (H-1-H-1 COSY, HMQC, HMBC, and NOESY) spectroscopy. Metabolites 1, 3 and 4 exhibited moderate to weak cytotoxicity to human tumor cell lines, HeLa, HEp-2, MCF-7 and MDA-MB-231.
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