Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 14, Issue 8, Pages 16866-16881Publisher
MDPI
DOI: 10.3390/ijms140816866
Keywords
ambulatory blood pressure; calcium channel blockers; cardiac hypertrophy; chronic kidney disease; heart rate variability; hypertension (kidney)
Funding
- Health and Labor Sciences Research grant
- Japanese Ministry of Education, Science, Sports and Culture
- Salt Science Research Foundation [1134]
- Yokohama Foundation for Advancement of Medical Science
- Kidney Foundation, Japan [JKFB13-17]
- Grants-in-Aid for Scientific Research [24890189, 25460906] Funding Source: KAKEN
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Ambulatory blood pressure (BP) and heart rate (HR) profile are proposed to be related to renal deterioration and cardiovascular complication in hypertension and chronic kidney disease (CKD). In this study, we examined the beneficial effects cilnidipine, a unique L/N-type calcium channel blocker (CCB), in addition to renin-angiotensin system inhibitors, on ambulatory BP and HR profile, as well as cardiorenal function in hypertensive CKD patients. Forty-five patients were randomly assigned to the cilnidipine replacement group (n = 21) or the control CCBs group (n = 24) during a 24-week active treatment period. Although clinical BP values were similar in the cilnidipine and control CCBs groups after the treatment period, the results of ambulatory BP monitoring showed that the 24-h and daytime systolic BP levels in the cilnidipine group were significantly lower compared with the control group after the study. Furthermore, the left ventricular mass index (LVMI) was significantly decreased in the cilnidipine group compared to the control group after the study (LVMI, 135.3 +/- 26.4 versus 181.2 +/- 88.4, p = 0.031), with a significant difference in the changes in the LVMI between the cilnidipine and control groups (change in LVMI, -12.4 +/- 23.7 versus 26.2 +/- 64.4, p = 0.007). These results indicate that cilnidipine is beneficial for the suppression of pathological cardiac remodeling, at least partly, via a superior improving effect on ambulatory BP profile compared with control CCBs in hypertensive CKD patients.
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