4.7 Review

Molecular Mechanisms of Ursodeoxycholic Acid Toxicity & Side Effects: Ursodeoxycholic Acid Freezes Regeneration & Induces Hibernation Mode

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Specific bile acids inhibit hepatic fatty acid uptake in mice

Biao Nie et al.

HEPATOLOGY (2012)

Article Oncology

Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining

Takahiro Oike et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)

Review Medicine, Research & Experimental

Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications

Marcelo G. Roma et al.

CLINICAL SCIENCE (2011)

Review Pharmacology & Pharmacy

Cancer Chemoprevention by Targeting the Epigenome

Joseph Huang et al.

CURRENT DRUG TARGETS (2011)

Article Gastroenterology & Hepatology

In PSC with Colitis Treated with UDCA, Most Colonic Carcinomas Develop in the First Years After the Start of Treatment

G. Rudolph et al.

DIGESTIVE DISEASES AND SCIENCES (2011)

Article Gastroenterology & Hepatology

Primary Biliary Cirrhosis

Bhavik M. Bhandari et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2011)

Article Gastroenterology & Hepatology

Evaluation of risk factors for the development of cirrhosis in autoimmune hepatitis: Japanese NHO-AIH prospective study

Kiyoshi Migita et al.

JOURNAL OF GASTROENTEROLOGY (2011)

Article Agriculture, Multidisciplinary

Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G(2)/M phase arrest and apoptosis

Hsueh-Chun Wang et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2011)

Article Gastroenterology & Hepatology

A 35-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre

Annarosa Floreani et al.

LIVER INTERNATIONAL (2011)

Article Gastroenterology & Hepatology

Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis

Yury Popov et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Review Biochemistry & Molecular Biology

Linking long-term toxicity of xeno-chemicals with short-term biological adaptation

Robert Barouki

BIOCHIMIE (2010)

Article Clinical Neurology

Converging Perturbed Microvasculature and Microglial Clusters Characterize Alzheimer Disease Brain

N. Jantaratnotai et al.

CURRENT ALZHEIMER RESEARCH (2010)

Article Pharmacology & Pharmacy

Targeting the p53 Pathway of Apoptosis

Joana D. Amaral et al.

CURRENT PHARMACEUTICAL DESIGN (2010)

Article Gastroenterology & Hepatology

Ursodeoxycholic acid treatment in patients with cystic fibrosis at risk for liver disease

Maria Siano et al.

DIGESTIVE AND LIVER DISEASE (2010)

Article Pharmacology & Pharmacy

A concentration-dependent effect of ursodeoxycholate on apoptosis and caspases activities of HepG2 hepatocellular carcinoma cells

Nikos J. Tsagarakis et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

Article Gastroenterology & Hepatology

Targets for Current Pharmacologic Therapy in Cholesterol Gallstone Disease

Agostino Di Ciaula et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2010)

Article Biochemical Research Methods

Fluorescence imaging of membrane dynamics in living cells

Petra Weber et al.

JOURNAL OF BIOMEDICAL OPTICS (2010)

Article Gastroenterology & Hepatology

In PSC with dominant bile duct stenosis, IBD is associated with an increase of carcinomas and reduced survival

Gerda Rudolph et al.

JOURNAL OF HEPATOLOGY (2010)

Review Biochemistry & Molecular Biology

Mitochondrial gateways to cancer

Lorenzo Galluzzi et al.

MOLECULAR ASPECTS OF MEDICINE (2010)

Review Chemistry, Medicinal

Cyanobacterial Cyclopeptides as Lead Compounds to Novel Targeted Cancer Drugs

Ioannis Sainis et al.

MARINE DRUGS (2010)

Editorial Material Gastroenterology & Hepatology

PRIMARY SCLEROSING CHOLANGITIS What is the role of ursodeoxycholic acid in therapy for PSC?

Roger W. Chapman

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2010)

Review Clinical Neurology

Inflammation in Neurological Disorders: A Help or a Hindrance?

V. Wee Yong

NEUROSCIENTIST (2010)

Editorial Material Gastroenterology & Hepatology

Management of gallstones and gallbladder disease in patients undergoing gastric bypass

Bernabe M. Quesada et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2010)

Article Multidisciplinary Sciences

Apoptosis and Modulation of Cell Cycle Control by Bile Acids in Human Leukemia T Cells

Carmela Fimognari et al.

NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS (2009)

Review Pharmacology & Pharmacy

Nuclear receptors as therapeutic targets in cholestatic liver diseases

Gernot Zollner et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Role of Nuclear Steroid Receptors in Apoptosis

Joana Amaral et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Article Pharmacology & Pharmacy

Predictors of Treatment Response in Chronic Hepatitis B

Grace L-H. Wong et al.

DRUGS (2009)

Article Gastroenterology & Hepatology

High-Dose Ursodeoxycholic Acid for the Treatment of Primary Sclerosing Cholangitis

Keith D. Lindor et al.

HEPATOLOGY (2009)

Review Immunology

Primary biliary cirrhosis

Simon Hohenester et al.

SEMINARS IN IMMUNOPATHOLOGY (2009)

Editorial Material Gastroenterology & Hepatology

Biochemical mechanisms in drug-induced liver injury: Certainties and doubts

Ignazio Grattagliano et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Review Gastroenterology & Hepatology

Bile-acid-induced cell injury and protection

Maria J. Perez et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Review Biochemistry & Molecular Biology

Structural biology of the tumor suppressor p53

Andreas C. Joerger et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation

In. H. Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Review Medicine, Research & Experimental

Nuclear factor-kB activation: From bench to bedside

Gautam Sethi et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2008)

Article Respiratory System

A single centre experience of liver disease in adults with cystic fibrosis 1995-2006

K. L. Nash et al.

JOURNAL OF CYSTIC FIBROSIS (2008)

Article Virology

Acute hepatitis A virus infection in Turkey

Andrea Normann et al.

JOURNAL OF MEDICAL VIROLOGY (2008)

Article Pediatrics

Review of historical cohort: ursodeoxycholic acid in extrahepatic biliary atresia

Magd A. Kotb

JOURNAL OF PEDIATRIC SURGERY (2008)

Article Gastroenterology & Hepatology

Is serum alanine transaminase level a reliable marker of histological disease in chronic hepatitis C infection?

Faisal M. Sanai et al.

LIVER INTERNATIONAL (2008)

Review Biochemistry & Molecular Biology

PUMA, a potent killer with or without p53

J. Yu et al.

ONCOGENE (2008)

Review Biochemistry & Molecular Biology

Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease

Rita M. Ramalho et al.

TRENDS IN MOLECULAR MEDICINE (2008)

Article Medicine, General & Internal

Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases

Michael Trauner et al.

WIENER MEDIZINISCHE WOCHENSCHRIFT (2008)

Article Biochemistry & Molecular Biology

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis

Joana D. Amaral et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Gastroenterology & Hepatology

Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes

Rui E. Castro et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

Article Gastroenterology & Hepatology

Long-term survival and impact of ursodeoxycholic acid treatment for recurrent primary biliary cirrhosis after liver transplantation

Phunchai Charatcharoenwitthaya et al.

LIVER TRANSPLANTATION (2007)

Article Gastroenterology & Hepatology

Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices

Christelle Guyot et al.

JOURNAL OF HEPATOLOGY (2007)

Review Cell Biology

Integrating cell-signalling pathways with NF-kappa B and IKK function

Neil D. Perkins

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Oncology

Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence

Sandeep Akare et al.

INTERNATIONAL JOURNAL OF CANCER (2006)

Article Medicine, Research & Experimental

Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy

Matthew R. Ritter et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Review Biochemistry & Molecular Biology

Introduction to NF-κB:: players, pathways, perspectives

T. D. Gilmore

ONCOGENE (2006)

Article Gastroenterology & Hepatology

Early treatment with ursodeoxycholic acid for cholestasis in children on parenteral nutrition because of primary intestinal failure

G. De Marco et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2006)

Article Gastroenterology & Hepatology

Long-term effects of mid-dose ursodeoxycholic acid in primary biliary cirrhosis: A meta-analysis of randomized controlled trials

Jian Shi et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)

Article Neurosciences

Unconjugated bilirubin activates and damages microglia

Ana C. Gordo et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2006)

Article Biochemistry & Molecular Biology

How does cellular senescence prevent cancer?

MD Lynch

DNA AND CELL BIOLOGY (2006)

Article Oncology

Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid

T Ikegami et al.

MOLECULAR CANCER THERAPEUTICS (2006)

Review Pharmacology & Pharmacy

Blocking the path to death: Anti-apoptotic molecules in ischemia/reperfusion injury of the liver

P. Georgiev et al.

CURRENT PHARMACEUTICAL DESIGN (2006)

Review Neurosciences

Microglial senescence: does the brain's immune system have an expiration date?

Wolfgang J. Streit

TRENDS IN NEUROSCIENCES (2006)

Review Biochemistry & Molecular Biology

Modulation of hepatocyte apoptosis: Cross-talk between bile acids and nuclear steroid receptors

S. Sola et al.

CURRENT MEDICINAL CHEMISTRY (2006)

Article Oncology

Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence

DS Alberts et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)

Article Pharmacology & Pharmacy

Inhibition of hepatocyte growth factor production in human fibroblasts by ursodeoxycholic acid

K Hiramatsu et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)

Article Gastroenterology & Hepatology

Ursodeoxycholic acid induced activation of the glucocorticoid receptor in primary rat hepatocytes

C Weitzel et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2005)

Article Infectious Diseases

Serum ALT levels as a surrogate marker for serum HBV DNA levels in HBeAg-negative pregnant women

P Sangfelt et al.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2004)

Article Gastroenterology & Hepatology

Prolonged follow-up of patients in the US multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis

B Combes et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2004)

Review Biochemistry & Molecular Biology

Unraveling V(D)J recombination: Insights into gene regulation

D Jung et al.

Review Pharmacology & Pharmacy

Detoxification of lithocholic acid, a toxic bile acid: Relevance to drug hepatotoxicity

AF Hofmann

DRUG METABOLISM REVIEWS (2004)

Article Chemistry, Medicinal

Ursodeoxycholic acid inhibits pro-inflammatory repertoires, IL-1β and nitric oxide in rat microglia

SS Joo et al.

ARCHIVES OF PHARMACAL RESEARCH (2003)

Article Multidisciplinary Sciences

Phosphatidylserine receptor is required for clearance of apoptotic cells

MO Li et al.

SCIENCE (2003)

Review Pharmacology & Pharmacy

Impact of drug transporter studies on drug discovery and development

N Mizuno et al.

PHARMACOLOGICAL REVIEWS (2003)

Article Gastroenterology & Hepatology

Primary sclerosing cholangitis in children: A long-term follow-up study

AE Feldstein et al.

HEPATOLOGY (2003)

Review Genetics & Heredity

What do human micronuclei contain?

H Norppa et al.

MUTAGENESIS (2003)

Review Oncology

The role of p53 in determining sensitivity to radiotherapy

AV Gudkov et al.

NATURE REVIEWS CANCER (2003)

Article Health Care Sciences & Services

Long-term survival and cause-specific mortality in patients with cirrhosis of the liver: a nationwide cohort study in Denmark

HT Sorensen et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2003)

Article Biochemistry & Molecular Biology

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53

WH Hoffman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Pathology

Cytokeratins as targets for bile acid-induced toxicity

P Fickert et al.

AMERICAN JOURNAL OF PATHOLOGY (2002)

Article Biotechnology & Applied Microbiology

Micronuclei induction, cell cycle delay and apoptosis as markers of cellular stress caused by ursodeoxycholic acid in human lymphocytes

C Fimognari et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2001)

Review Gastroenterology & Hepatology

Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'

KN Lazaridis et al.

JOURNAL OF HEPATOLOGY (2001)

Article Gastroenterology & Hepatology

Epidemiology and natural history of primary biliary cirrhosis in a US community

WR Kim et al.

GASTROENTEROLOGY (2000)

Article Infectious Diseases

Response-adjusted α-interferon therapy for chronic hepatitis C in HIV-infected patients

T Prestileo et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2000)

Article Biochemistry & Molecular Biology

Comparison of the effects of bile acids on cell viability and DNA synthesis by rat hepatocytes in primary culture

MC Martinez-Diez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2000)