Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 13, Issue 12, Pages 15588-15600Publisher
MDPI
DOI: 10.3390/ijms131215588
Keywords
integrins; Lewis y antigen; ovarian caricinoma; chemoresistance
Funding
- National Natural Science Foundation of China [30872757, 81072118, 81172491, 81101527]
- Ph. D. Programs Foundation of Ministry of Education of China [20112104110016, 20112104120019]
- Science Committee Foundation of Shenyang City, China [F10-14-9-9-52]
- Shengjing Free Researcher Project [200807]
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Objective: To measure Lewis y and integrin alpha(5)beta(1) expression in epithelial ovarian carcinoma and to correlate the levels of these molecules with ovarian carcinoma chemotherapy and prognosis. Methods: The study population included 34 ovarian carcinoma patients with chemotherapeutic drug-resistance, six partially drug-sensitive cases, and 52 drug-sensitive cases (92 total). Immunochemistry was used to determine expression of Lewis y antigen and integrin alpha(5)beta(1) in ovarian carcinoma tissues, and correlation of these molecules with chemotherapy resistance was further investigated, Multi-factor logistic regression analysis was applied to investigate: age, surgical stage, grade, subtype of patient cases, metastasis of lymph nodes, residual tumor size, expression levels of Lewis y antigen and integrin alpha(5)beta(1) correlation with ovarian carcinoma chemotherapy resistance. Results: The expression rates of Lewis y antigen and integrins alpha(5) and beta(1) were significantly greater in the drug-resistant group (91.17%, 85.29%, 88.24%) than the partially sensitive (50.00%, 33.33%, 50.00%) or sensitive groups (61.54%, 57.69%, 55.77%). Binary logistic regression analysis revealed that surgical stage, residual tumor size, and expression of integrin alpha(5) and Lewis y in ovarian carcinoma tissues were independent risk factors for chemotherapeutic drug resistance. Conclusions: Overexpression of Lewis y and integrin alpha(5) are strong risk factors for chemotherapeutic drug resistance in ovarian carcinoma patients.
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