Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 12, Issue 4, Pages 2158-2173Publisher
MDPI
DOI: 10.3390/ijms12042158
Keywords
bacteriocins; electrospinning; nanofiber; antimicrobial activity
Funding
- Cipla Medpro (Pty) Ltd
- National Research Foundation, South Africa
- South African Research Chairs Initiative of the Department of Science and Technology
- National Research Foundation
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Plantaricin 423, produced by Lactobacillus plantarum, and bacteriocin ST4SA produced by Enterococcus mundtii, were electrospun into nanofibers prepared from different combinations of poly(D, L-lactide) (PDLLA) and poly(ethylene oxide) (PEO) dissolved in N,N-dimethylformamide (DMF). Both peptides were released from the nanofibers with a high initial burst and retained 88% of their original antimicrobial activity at 37 degrees C. Nanofibers have the potential to serve as carrier matrix for bacteriocins and open a new field in developing controlled antimicrobial delivery systems for various applications.
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