4.7 Review

Adaptation of High-Throughput Screening in Drug Discovery-Toxicological Screening Tests

Related references

Note: Only part of the references are listed.
Review Environmental Sciences

Genetic Toxicology in the 21st Century: Reflections and Future Directions

Brinda Mahadevan et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2011)

Article Pharmacology & Pharmacy

From alternative methods to a new toxicology

Thomas Hartung

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2011)

Meeting Abstract Toxicology

How can stem cell technologies be applied to replace animal use in toxicity testing?

I. A. Cotgreave

TOXICOLOGY LETTERS (2011)

Review Biotechnology & Applied Microbiology

High-throughput process development for biopharmaceutical drug substances

Rahul Bhambure et al.

TRENDS IN BIOTECHNOLOGY (2011)

Review Pharmacology & Pharmacy

The Drug Discovery Portal: a resource to enhance drug discovery from academia

Rachel L. Clark et al.

DRUG DISCOVERY TODAY (2010)

Article Cell Biology

In vivo RNAi: Today and Tomorrow

Norbert Perrimon et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Review Pharmacology & Pharmacy

In silico toxicology for the pharmaceutical sciences

Luis G. Valerio

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

Article Toxicology

Bringing toxicology into the 21st century: A global call to action

T. Seidle et al.

TOXICOLOGY IN VITRO (2009)

Review Biotechnology & Applied Microbiology

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research

Tiago G. Fernandes et al.

TRENDS IN BIOTECHNOLOGY (2009)

Article Engineering, Biomedical

Micro-stamped surfaces for the patterned growth of neural stem cells

Ana Ruiz et al.

BIOMATERIALS (2008)

Review Pharmacology & Pharmacy

Bright future of optical assays for ion channel drug discovery

Mena Molokanova et al.

DRUG DISCOVERY TODAY (2008)

Review Pharmacology & Pharmacy

Understanding mechanisms of toxicity: Insights from drug discovery research

Keith A. Houck et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)

Review Toxicology

Computational toxicology - A state of the science mini review

Robert J. Kavlock et al.

TOXICOLOGICAL SCIENCES (2008)

Article Multidisciplinary Sciences

Three-dimensional cellular microarray for high-throughput toxicology assays

Moo-Yeal Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemical Research Methods

The future of high-throughput screening

Lorenz M. Mayr et al.

JOURNAL OF BIOMOLECULAR SCREENING (2008)

Article Biotechnology & Applied Microbiology

Microscale culture of human liver cells for drug development

Salman R. Khetani et al.

NATURE BIOTECHNOLOGY (2008)

Article Toxicology

The use of human cell line reporter gene-based assays in chemical toxicity testing

Michelle Scrivens et al.

TOXICOLOGY IN VITRO (2007)

Article Biochemical Research Methods

Micro-bioreactor array for controlling cellular microenvironments

Elisa Figallo et al.

LAB ON A CHIP (2007)

Review Pharmacology & Pharmacy

Application of data mining approaches to drug delivery

Sean Ekins et al.

ADVANCED DRUG DELIVERY REVIEWS (2006)

Article Chemistry, Medicinal

Future of toxicologys - Predictive toxicology: An expanded view of chemical toxicity

Ann M. Richard

CHEMICAL RESEARCH IN TOXICOLOGY (2006)

Article Biochemical Research Methods

Live cell quality control and utility of real-time cell electronic sensing for assay development

Shelli L. Kirstein et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2006)

Article Biochemistry & Molecular Biology

Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast

Ainslie B. Parsons et al.

Article Biochemical Research Methods

A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase

Philip E. Brandish et al.

JOURNAL OF BIOMOLECULAR SCREENING (2006)

Review Biochemistry & Molecular Biology

High content cellular screening

Oliver Rausch

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Identifying off-target effects and hidden phenotypes of drugs in human cells

Marnie L. MacDonald et al.

NATURE CHEMICAL BIOLOGY (2006)

Review Biotechnology & Applied Microbiology

Cellular imaging in drug discovery

P Lang et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Review Biochemistry & Molecular Biology

High-throughput screening of biocatalytic activity: applications in drug discovery

RA Kumar et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Review Biochemistry & Molecular Biology

Molecular and functional analysis using live cell microarrays

DS Chen et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2006)

Review Pharmacology & Pharmacy

The challenge of predicting drug toxicity in silico

Angelo Vedani et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2006)

Article Biotechnology & Applied Microbiology

A low volume, high-throughput forward mutation assay in Salmonella typhimurium based on fluorouracil resistance

JE Miller et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)

Article Biochemistry & Molecular Biology

Caenorhabditis elegans gcs-1 confers resistance to arsenic-induced oxidative stress

VHC Liao et al.

BIOMETALS (2005)

Article Multidisciplinary Sciences

Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses

MY Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Biological spectra analysis: Linking biological activity profiles to molecular structure

AF Fliri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Environmental Sciences

Assessing behavioral toxicity with Caenorhabditis elegans

GL Anderson et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2004)

Article Biotechnology & Applied Microbiology

Assessment of the performance of the Ames II™ assay:: a collaborative study with 19 coded compounds

S Flückiger-Isler et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2004)

Article Toxicology

Developmental toxicity of the dithiocarbamate pesticide sodium metam in zebrafish

MA Haendel et al.

TOXICOLOGICAL SCIENCES (2004)

Article Chemistry, Multidisciplinary

Arrays for the combinatorial exploration of cell adhesion

BP Orner et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Article Biochemical Research Methods

Polyplexes and lipoplexes for mammalian gene delivery:: From traditional to microarray screening

SE How et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2004)

Review Biochemical Research Methods

High throughput screening of genetic polymorphisms by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

G Corona et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2004)

Article Multidisciplinary Sciences

Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens

SN Bailey et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biochemistry & Molecular Biology

Pursuing the leadlikeness concept in pharmaceutical research

MM Hann et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2004)

Review Pharmacology & Pharmacy

Current trends in modern pharmaceutical analysis for drug discovery

HL Koh et al.

DRUG DISCOVERY TODAY (2003)

Review Cell Biology

Looking forward to seeing calcium

R Rudolf et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Biochemical Research Methods

Development of a versatile platform for nuclear receptor screening using AlphaScreen™

N Rouleau et al.

JOURNAL OF BIOMOLECULAR SCREENING (2003)

Article Endocrinology & Metabolism

A homogeneous in vitro functional assay for estrogen receptors:: Coactivator recruitment

JW Liu et al.

MOLECULAR ENDOCRINOLOGY (2003)

Article Biochemical Research Methods

Integration of NMR and high-throughput screening

PJ Hajduk et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2002)

Review Pharmacology & Pharmacy

Structure-based virtual screening: an overview

PD Lyne

DRUG DISCOVERY TODAY (2002)

Review Pharmacology & Pharmacy

Multi-component reactions and evolutionary chemistry

L Weber

DRUG DISCOVERY TODAY (2002)

Article Chemistry, Medicinal

A high-throughput HERG potassium channel function assay: An old assay with a new look

CS Cheng et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2002)

Review Pharmacology & Pharmacy

Ion-channel assay technologies:: quo vadis?

J Xu et al.

DRUG DISCOVERY TODAY (2001)

Article Pharmacology & Pharmacy

[3H]dofetilide binding to HERG transfected membranes:: a potential high throughput preclinical screen

K Finlayson et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2001)

Review Biochemistry & Molecular Biology

The computational prediction of toxicity

MD Barratt et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2001)

Review Biochemistry & Molecular Biology

Techniques for analysis and purification in high-throughput chemistry

I Hughes et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2001)

Review Biotechnology & Applied Microbiology

COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics

DFV Lewis

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2001)