Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 12, Issue 7, Pages 4395-4413Publisher
MDPI
DOI: 10.3390/ijms12074395
Keywords
nanomaterials; anticancer drugs; paclitaxel; drug carrier; drug delivery
Funding
- National Basic Research Program of China (973 Program) [2010CB933504]
- National Science Foundation of China [90913006, 21077068]
- Shandong Provincial Natural Science Foundation [ZR2010BM017]
- American Lebanese Syrian Associated Charities (ALSAC)
- St. Jude Children's Research Hospital
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Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. This review takes paclitaxel as an example and compares different nanoparticle-based delivery systems for their effectiveness in cancer chemotherapy.
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