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EUROPEAN JOURNAL OF NEUROLOGY (2005)
A synthetic derivative of the natural product rocaglaol is a potent inhibitor of cytokine-mediated signaling and shows neuroprotective activity in vitro and in animal models of Parkinson's disease and traumatic brain injury
T Fahrig et al.
MOLECULAR PHARMACOLOGY (2005)
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
L Chen et al.
NATURE NEUROSCIENCE (2005)
Free radical scavengers and antioxidants from lemongrass (Cymbopogon citratus (DC.) Stapf.)
J Cheel et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)
Aggregated α-synuclein activates microglia:: a process leading to disease progression in Parkinson's disease
W Zhang et al.
FASEB JOURNAL (2005)
Brain, aging and neurodegeneration: Role of zinc ion availability
E Mocchegiani et al.
PROGRESS IN NEUROBIOLOGY (2005)
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease
E Greggio et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Parkinson's disease: in vivo assessment of disease progression using positron emission tomography
WL Au et al.
MOLECULAR BRAIN RESEARCH (2005)
Pathogenic effects of α-synuclein aggregation
D Lundvig et al.
MOLECULAR BRAIN RESEARCH (2005)
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
CM Testa et al.
MOLECULAR BRAIN RESEARCH (2005)
Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease
S Sato et al.
NEUROLOGY (2005)
Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport
H Takeuchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Redox interactions of nitric oxide with dopamine and its derivatives
F Antunes et al.
TOXICOLOGY (2005)
Plasma homocysteine levels in Parkinson's disease: role of antiparkinsonian medications
S Zoccolella et al.
PARKINSONISM & RELATED DISORDERS (2005)
The xanthine oxidase inhibitory activity and hypouricemia effect of the propolis in rats
K Yoshizumi et al.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN (2005)
Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease
K Xu et al.
PHARMACOLOGY & THERAPEUTICS (2005)
Activation of p38 and N-acetylcysteine-sensitive c-Jun NH2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids
IG Onyango et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide
H Liu et al.
PHARMACOLOGICAL RESEARCH (2005)
Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum
H Kabuto et al.
NEUROCHEMICAL RESEARCH (2005)
Parkinson's disease risk factors: genetic, environmental, or both?
MF Allam et al.
NEUROLOGICAL RESEARCH (2005)
Inhibition of vesicular monoamine transporter enhances vulnerability of dopaminergic cells: relevance to Parkinson's disease
HJ Choi et al.
NEUROCHEMISTRY INTERNATIONAL (2005)
Prevention of reactive oxygen species-induced oxidative stress in human microvascular endothelial cells by green tea polyphenol
DK Rah et al.
TOXICOLOGY LETTERS (2005)
Extracellular metabolites in the cortex and hippocampus of epileptic patients
I Cavus et al.
ANNALS OF NEUROLOGY (2005)
Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases
MBH Youdim et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
JT Slevin et al.
JOURNAL OF NEUROSURGERY (2005)
Microglial activation and dopamine terminal loss in early Parkinson's disease
Y Ouchi et al.
ANNALS OF NEUROLOGY (2005)
Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (±)-naringenin
F Orallo et al.
PLANTA MEDICA (2005)
A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease
M Bahat-Stroomza et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Anti-inflammatory effect of heme oxygenase 1: Glycosylation and nitric oxide inhibition in macrophages
HY Lin et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Multifunctional activities of green tea catechins in neuroprotection - Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway
SA Mandel et al.
NEUROSIGNALS (2005)
Therapeutic potential of neurotrophic factors in neurodegenerative diseases
YS Levy et al.
BIODRUGS (2005)
Targeting the JNK Signaling Pathway for Stroke and Parkinson's Diseases Therapy
Chia-Yi Kuan et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
The proteomics of neurodegeneration
MD Johnson et al.
AMERICAN JOURNAL OF PHARMACOGENOMICS (2005)
Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity
KJ Woo et al.
FEBS LETTERS (2005)
Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety
S Khatib et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Garlic extract attenuates hyperhomocysteinemia caused by folic acid deficiency in the rat
YY Yeh et al.
NUTRITION RESEARCH (2005)
Physiological activity of irradiated green tea polyphenol on the human skin
BJ An et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2005)
Curcumin induces glutathione biosynthesis and inhibits NF-kappa B activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity
SK Biswas et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
Inflammatory process in Parkinson's disease: Role for cytokines
T Nagatsu et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica
T Masuda et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2005)
A critical review of the function of neuromelanin and an attempt to provide a unified theory
BJR Nicolaus
MEDICAL HYPOTHESES (2005)
Effects of creatine treatment on the survival of dopaminergic neurons in cultured fetal ventral mesencephalic tissue
RH Andres et al.
NEUROSCIENCE (2005)
Effect of angiotensin-converting enzyme inhibitor perindopril on interneurons in MPTP-treated mice
R Kurosaki et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2005)
Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression
SH Kim et al.
PHARMACOLOGICAL RESEARCH (2004)
PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP
CC Chio et al.
CELLULAR SIGNALLING (2004)
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-α by 2′-hydroxychalcone derivatives in RAW 264.7 cells
HS Ban et al.
BIOCHEMICAL PHARMACOLOGY (2004)
The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro
EA Mazzio et al.
BRAIN RESEARCH (2004)
Reaction of iron(III) with theaflavin: complexation and oxidative products
M O'Coinceanainn et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2004)
Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells
EA Mazzio et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study
H Watanabe et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2004)
Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease
ME van Meeteren et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages
M Blonska et al.
JOURNAL OF ETHNOPHARMACOLOGY (2004)
Inhibitory effects of esculetin on melanin biosynthesis
Y Masamoto et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)
(-)-epigallocatech in-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production
DS Kim et al.
ARCHIVES OF PHARMACAL RESEARCH (2004)
Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokine-stimulated microglia
CJ Chen et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats
IH Wei et al.
BRAIN RESEARCH (2004)
Oxidative coupling of epigallocatechin gallate amplifies antioxidant activity and inhibits xanthine oxidase activity
M Kurisawa et al.
CHEMICAL COMMUNICATIONS (2004)
Inhibitory effects of hexylresorcinol and dodecylresorcinol on mushroom (Agaricus bisporus) tyrosinase
QX Chen et al.
PROTEIN JOURNAL (2004)
SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease
WY Wang et al.
NEUROSCIENCE RESEARCH (2004)
Effect of silybin on phorbol myristate actetate-induced protein kinase C translocation, NADPH oxidase activity and apoptosis in human neutrophils
Z Varga et al.
PHYTOMEDICINE (2004)
Major flavonoids in grape seeds and skins: Antioxidant capacity of catechin, epicatechin, and gallic acid
Y Yilmaz et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)
Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells
C Hu et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)
Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging
CKB Ferrari
BIOGERONTOLOGY (2004)
Diabetes mellitus and progression of rigidity and gait disturbance in older persons
Z Arvanitakis et al.
NEUROLOGY (2004)
Inhibition of nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells by synthetic flavones: Structure-activity relationship and action mechanism
SJ Kim et al.
ARCHIVES OF PHARMACAL RESEARCH (2004)
Mice lacking α-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration
RE Drolet et al.
NEUROTOXICOLOGY (2004)
Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro
S Tanaka et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Effect of anthocyanins contained in a blackberry extract on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat
L Sautebin et al.
PLANTA MEDICA (2004)
Constituents in Easter lily flowers with medicinal activity
JA Francis et al.
LIFE SCIENCES (2004)
Heme oxygenase expression in human central nervous system disorders
HM Schipper
FREE RADICAL BIOLOGY AND MEDICINE (2004)
The neuromelanin of human substantia nigra: Physiological and pathogenic aspects
FA Zucca et al.
PIGMENT CELL RESEARCH (2004)
JNK inhibition as a potential strategy in treating Parkinson's disease
WY Wang et al.
DRUG NEWS & PERSPECTIVES (2004)
Effect of flavonoids and Vitamin E on cyclooxygenase-2 (COX-2) transcription
KA O'Leary et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2004)
Free radical scavengers and antioxidants from Baccharis grisebachii
A Tapia et al.
JOURNAL OF ETHNOPHARMACOLOGY (2004)
Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver
JX Zhu et al.
JOURNAL OF ETHNOPHARMACOLOGY (2004)
Inhibitory effects of active compounds isolated from safflower (Carthamus tinctorius L.) seeds for melanogenesis
JS Roh et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)
Selenium and brain function:: a poorly recognized liaison
U Schweizer et al.
BRAIN RESEARCH REVIEWS (2004)
Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium linn.
C Selvam et al.
PHYTOTHERAPY RESEARCH (2004)
Role of dietary iron restriction in a mouse model of Parkinson's disease
CW Levenson et al.
EXPERIMENTAL NEUROLOGY (2004)
Does cellular iron dysregulation play a causative role in Parkinson's disease?
D Kaur et al.
AGEING RESEARCH REVIEWS (2004)
Effect of estrogen receptor agonists treatment in MPTP mice:: evidence of neuroprotection by an ERα agonist
M D'Astous et al.
NEUROPHARMACOLOGY (2004)
Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains
M Naoi et al.
NEUROTOXICOLOGY (2004)
Hemin/nitrite/H2O2 induces brain homogenate oxidation and nitration:: effects of some flavonoids
YL Zhao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2004)
Antioxidant and free radical-scavenging activity of Choto-san and its related constituents
P Mahakunakorn et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2004)
Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities
KC Fylaktakidou et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils
Y O'Dowd et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships
WC Ko et al.
BIOCHEMICAL PHARMACOLOGY (2004)
New insights into iron release from ferritin: direct observation of the neurotoxin 6-hydroxydopamine entering ferritin and reaching redox equilibrium with the iron core
GNL Jameson et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats
M Yagisawa et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)
Neuroprotective effects of (-)-epigallocatechin gallate after hypoxia-ischemia-induced brain damage: novel mechanisms of action
BA Sutherland et al.
FASEB JOURNAL (2004)
Resveratrol analogues as selective cyclooxygenase-2 inhibitors:: synthesis and structure-activity relationship
M Murias et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Spice phenolics inhibit human PMNL 5-lipoxygenase
NS Prasad et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2004)
Prenylated flavonoids as tyrosinase inhibitors
NK Lee et al.
ARCHIVES OF PHARMACAL RESEARCH (2004)
Could a loss of α-synuclein function put dopaminergic neurons at risk?
RG Perez et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Anti-inflammatory plant flavonoids and cellular action mechanisms
HP Kim et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2004)
Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-{3-[4-(4-chlorophenyl)-l-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro model of cell death and in Mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
A Iwashita et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Transglutaminases - Possible Drug Targets in Human Diseases
Vittorio Gentile et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2004)
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by butein in RAW 264.7 cells
SH Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro
ZH Shao et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2004)
Iron and alpha-synuclein in the substantia nigra of MPTP-treated Mice
S Mandel et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2004)
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice
Y Wang et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2004)
Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development
T Takahashi et al.
CANCER SCIENCE (2004)
Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers
O Nerya et al.
PHYTOCHEMISTRY (2004)
Effects of major dietary antioxidants on inflammatory markers of RAW 264.7 macrophages
WJ Jung et al.
BIOFACTORS (2004)
Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives
HY Cho et al.
PHARMACOLOGICAL RESEARCH (2004)
Reaction rate constants of superoxide scavenging by plant antioxidants
D Taubert et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc
P Zatta et al.
BRAIN RESEARCH BULLETIN (2003)
Protective effects of green tea polyphenol against reactive oxygen species-induced oxidative stress in cultured rat calvarial osteoblast
YH Park et al.
CELL BIOLOGY AND TOXICOLOGY (2003)
Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate- and Fe-microsomal systems
D Ozgová et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line
K Sakata et al.
CANCER LETTERS (2003)
Silibinin protects mice from T cell-dependent liver injury
J Schümann et al.
JOURNAL OF HEPATOLOGY (2003)
Therapeutic administration of 3,4,5-trimethoxy-4′-fluorochalcone, a selective inhibitor of iNOS expression, attenuates the development of adjuvant-induced arthritis in rats
J Rojas et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2003)
Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice
G Battaglia et al.
NEUROPHARMACOLOGY (2003)
Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
H Lee et al.
FASEB JOURNAL (2003)
Cyanidin and cyanidin 3-O-β-D-glucoside as DNA cleavage protectors and antioxidants
R Acquaviva et al.
CELL BIOLOGY AND TOXICOLOGY (2003)
Effect of O-glycosilation on the antioxidant activity and free radical reactions of a plant flavonoid, chrysoeriol
B Mishra et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins
DH Hyun et al.
JOURNAL OF NEUROCHEMISTRY (2003)
The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-α in C6 cells:: involvement of AP-1 and NFκB
JK Lee et al.
LIFE SCIENCES (2003)
On-line screening methods for antioxidants scavenging superoxide anion radical and hydrogen peroxide by liquid chromatography with indirect chemiluminescence detection
T Toyo'oka et al.
TALANTA (2003)
Nitric oxide and reactive oxygen species in Parkinson's disease
K Tieu et al.
IUBMB LIFE (2003)
Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids
Z Sroka et al.
FOOD AND CHEMICAL TOXICOLOGY (2003)
Role of dopamine transporter against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice
R Kurosaki et al.
METABOLIC BRAIN DISEASE (2003)
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease
RB Parsons et al.
NEUROSCIENCE LETTERS (2003)
NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
DC Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action
H Matsuda et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Cytoprotection of pyruvic acid and reduced β-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells
EA Mazzio et al.
NEUROCHEMICAL RESEARCH (2003)
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
P Teismann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Iron misregulation in the brain: a primary cause of neurodegenerative disorders
Y Ke et al.
LANCET NEUROLOGY (2003)
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: A novel therapy for Parkinson's disease
D Kaur et al.
NEURON (2003)
Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action
CD Sadik et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Gnetol as a potent tyrosinase inhibitor from genus Gnetum
K Ohguchi et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2003)
Radiolysis of kaempferol in water/methanol mixtures. Evaluation of antioxidant activity of kaempferol and products formed
A Marfak et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2003)
Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots
O Nerya et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2003)
D-(+)-Glucose rescue against 1-methyl-4-phenylpyridinium toxicity through anaerobic glycolysis in neuroblastoma cells
E Mazzio et al.
BRAIN RESEARCH (2003)
Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro
E Mazzio et al.
NEUROSCIENCE LETTERS (2003)
Dietary flavonoid iron complexes as cytoprotective superoxide radical scavengers
MY Moridani et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Structure-activity relationship studies on chalcone derivatives: The potent inhibition of chemical mediators release
HH Ko et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2003)
Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappa B pathway in lipopolysaccharide-stimulated macrophage
SY Cho et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2003)
Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells
J O'Prey et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1
HY Lin et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
P Klivenyi et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2003)
Effect of Rhus coriaria L. (Anacardiaceae) on superoxide radical scavenging and xanthine oxidase activity
F Candan
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2003)
Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins
NP Seeram et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2003)
Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds
J Yamakoshi et al.
PIGMENT CELL RESEARCH (2003)
Dehydroepiandrosterone (DHEA) such as 17 beta-estradiol prevents MPTP-induced dopamine depletion in mice
M D'Astous et al.
SYNAPSE (2003)
MPP plus analogs acting on mitochondria and inducing neuro-degeneration
Y Kotake et al.
CURRENT MEDICINAL CHEMISTRY (2003)
Constituents of the fruits and leaves of Euodia daniellii
SW Yoo et al.
ARCHIVES OF PHARMACAL RESEARCH (2002)
Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation
MJ Wang et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
Iron and copper chelation by flavonoids:: an electrospray mass spectrometry study
MT Fernandez et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin
A Russo et al.
FITOTERAPIA (2002)
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay
U Huss et al.
JOURNAL OF NATURAL PRODUCTS (2002)
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
WZ Duan et al.
ANNALS OF NEUROLOGY (2002)
Antioxidant and free-radical scavenging activity of constituents of the leaves of Tachigalia paniculata
G Cioffi et al.
JOURNAL OF NATURAL PRODUCTS (2002)
Iron toxicity and antioxidant nutrients
CG Fraga et al.
TOXICOLOGY (2002)
A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism
AS Mandir et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Role of nitric oxide synthase against MPTP neurotoxicity in mice
R Kurosaki et al.
NEUROLOGICAL RESEARCH (2002)
The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia - Relevance to nigral neuronal death and striatal neurochemical changes
PA Serra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids
DEC Van Hoorn et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra
ZH Feng et al.
NEUROSCIENCE LETTERS (2002)
Glutathione, iron and Parkinson's disease
S Bharath et al.
BIOCHEMICAL PHARMACOLOGY (2002)
The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages
A Rossi et al.
PHYTOMEDICINE (2002)
N-methylation underlying Parkinson's disease
K Matsubara et al.
NEUROTOXICOLOGY AND TERATOLOGY (2002)
Influence of neuromelanin on oxidative pathways within the human substantia nigra
KL Double et al.
NEUROTOXICOLOGY AND TERATOLOGY (2002)
Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate
JY Choi et al.
NEUROTOXICOLOGY (2002)
Epigallocatechin-3-gallate inhibits interleukin-1β-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes -: Suppression of nuclear factor κB activation by degradation of the inhibitor of nuclear factor κB
R Singh et al.
ARTHRITIS AND RHEUMATISM (2002)
Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique
JY Lin et al.
LIFE SCIENCES (2002)
Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease
K Sriram et al.
FASEB JOURNAL (2002)
Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase
T Schewe et al.
JOURNAL OF NUTRITION (2002)
Indomethacin protects against neurodegeneration caused by MPTP intoxication in mice
I Kurkowska-Jastrzebska et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2002)
Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages
JS Kang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu,Zn superoxide dismutase
F Fornai et al.
NEUROSCIENCE LETTERS (2002)
Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease
BJ Tabner et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit
K Sasaki et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2002)
Phenylethanolarnine N-methyltransferase has β-carboline 2N-methyltransferase activity:: hypothetical relevance to Parkinson's disease
DA Gearhart et al.
NEUROCHEMISTRY INTERNATIONAL (2002)
Molecular modeling of flavonoids that inhibits xanthine oxidase
CM Lin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys
A Noda et al.
BRAIN RESEARCH (2002)
Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line
T Banerjee et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2002)
Role of mitogen-activated protein kinases in inducible nitric oxide synthase and TNFα expression in human fetal astrocytes
LWL Hua et al.
JOURNAL OF NEUROIMMUNOLOGY (2002)
Vesicle permeabilization by protofibrillar α-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism
MJ Volles et al.
BIOCHEMISTRY (2002)
The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
L Zecca et al.
FEBS LETTERS (2002)
Neuroprotection by adenosine A(2A) receptor blockade in experimental models of Parkinson's disease
K Ikeda et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic, neurons in models of Parkinson's disease
W Duan et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy
T Nagatsu
JOURNAL OF NEURAL TRANSMISSION (2002)
Amperometric biosensor based on a functionalized gold electrode for the detection of antioxidants
S Ignatov et al.
BIOSENSORS & BIOELECTRONICS (2002)
Iron complexes of deferiprone and dietary plant catechols as cytoprotective superoxide radical scavengers
MY Moridani et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
YS Du et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Effect of various agents on adenosine triphosphate synthesis in mitochondrial complex I deficiency
M Bar-Meir et al.
JOURNAL OF PEDIATRICS (2001)
Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils
L Selloum et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Antioxidant activities of polyphenols from sage (Salvia officinalis)
YR Lu et al.
FOOD CHEMISTRY (2001)
Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2
HP Kim et al.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2001)
Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: Cyclooxygenases and lipoxygenases
YS Chi et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
D Blum et al.
PROGRESS IN NEUROBIOLOGY (2001)
Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease
S Thobois et al.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY (2001)
3,4-Dihydroxyphenylacetaldehyde and hydrogen peroxide generate a hydroxyl radical: possible role in Parkinson's disease pathogenesis
SW Li et al.
MOLECULAR BRAIN RESEARCH (2001)
Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration
Y Levites et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Caffeine: a well known but little mentioned compound in plant science
H Ashihara et al.
TRENDS IN PLANT SCIENCE (2001)
Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP)
M Takanashi et al.
PARKINSONISM & RELATED DISORDERS (2001)
Partial purification of polyphenol oxidase from Chinese Brassica rapa L.
T Nagai et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)
Dimethyl sulfide, a volatile flavor constituent, is a slow-binding inhibitor of tyrosinase
M Pérez-Gilabert et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
A new caffeine biosynthetic pathway in tea leaves:: utilisation of adenosine released from the S-adenosyl-L-methionine cycle
C Koshiishi et al.
FEBS LETTERS (2001)
Silybin, a new iron-chelating agent
M Borsari et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2001)
The kinetics and mechanisms of the reaction of iron(III) with gallic acid, gallic acid methyl ester and catechin
MJ Hynes et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2001)
Micronutrient accumulation and depletion in schizophrenia, epilepsy, autism and Parkinson's disease?
S Johnson
MEDICAL HYPOTHESES (2001)
Partial purification and characterization of polyphenol oxidase fron banana (Musa sapientum L.) peel
CP Yang et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)
Effects of wine phenolics and sorghum tannins on tyrosinase activity and growth of melanoma cells
C Gómez-Cordovés et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)
Reduction of rat brain levels of the endogenous dopaminergic proneurotoxins 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-β-carboline by cigarette smoke
R Soto-Otero et al.
NEUROSCIENCE LETTERS (2001)
Is Parkinson's disease the heterozygote form of Wilson's disease: PD=1/2 WD?
S Johnson
MEDICAL HYPOTHESES (2001)
Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
GM Raso et al.
LIFE SCIENCES (2001)
Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents
M Tariq et al.
BRAIN RESEARCH BULLETIN (2001)
Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP
OA Andreassen et al.
EXPERIMENTAL NEUROLOGY (2001)
Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
T Dehmer et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Analysis of VMAT2 binding after methamphetamine or MPTP treatment: Disparity between homogenates and vesicle preparations
KA Hogan et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Conjugation position of quercetin glucuronides and effect on biological activity
AJ Day et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Enzyme inhibition and protein-binding action of the procyanidin-rich French maritime pine bark extract, pycnogenol: Effect on xanthine oxidase
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)
Inhibitors of 15-lipoxygenase from orange peel
KE Malterud et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)
Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione induced DNA single strand breaks in Caco-2 cells
SA Aherne et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Inhibition of type 4 phosphodiesterase by rolipram and Ginkgo biloba extract (EGb 761) decreases agonist-induced rises in internal calcium in human endothelial cells
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced complex I inhibition is reversed by disulfide reductant, dithiothreitol in mouse brain
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NEUROSCIENCE LETTERS (2000)
Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3′-digallate, (-)-epigallocatechin-3-gallate, and propyl gallate
JK Lin et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)
Flavonols from Heterotheca inuloides:: Tyrosinase inhibitory activity and structural criteria
I Kubo et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2000)
Inhibition of enzymatic browning and protection of sulfhydryl enzymes by thiol compounds
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PHYTOCHEMISTRY (2000)
Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX 2 gene expression via suppression of nuclear factor-κB activation
YC Chen et al.
BIOCHEMICAL PHARMACOLOGY (2000)
Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity
P Klivenyi et al.
NEUROREPORT (2000)
Neuroprotection by sodium salicylate against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
KP Mohanakumar et al.
BRAIN RESEARCH (2000)
Metals and neuroscience
AI Bush
CURRENT OPINION IN CHEMICAL BIOLOGY (2000)
Differential inhibition of multiple cAMP phosphodiesterase isozymes by isoflavones and tyrphostins
MR Nichols et al.
MOLECULAR PHARMACOLOGY (2000)
Molecular design of antibrowning agents
I Kubo et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)
On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the fenton reaction of the iron-ATP complex
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BIOMETALS (2000)
Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
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PROGRESS IN NEUROBIOLOGY (2000)
MPTP activates c-Jun NH2-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
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JOURNAL OF NEUROCHEMISTRY (2000)
Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase
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JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2000)
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