Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 12, Issue 5, Pages 2946-2957Publisher
MDPI
DOI: 10.3390/ijms12052946
Keywords
biosensor; cancer marker; galectin-3; galactose; single-walled carbon nanotubes
Funding
- Inje-University
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D-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the D-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the D-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that D-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.
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