Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 12, Issue 12, Pages 9265-9276Publisher
MDPI AG
DOI: 10.3390/ijms12129265
Keywords
miRNA; embryonic stem cell; MiRaGE metheod
Funding
- KAKENHI [2, 3300357, 2, 3501264]
- MEXT, Japan
- Grants-in-Aid for Scientific Research [23300357] Funding Source: KAKEN
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MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.
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