Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 12, Issue 1, Pages 114-127Publisher
MDPI AG
DOI: 10.3390/ijms12010114
Keywords
nonylphenol; brain; oxidative stress; behavior impairment
Funding
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [07KJA36029]
- Key Laboratory of Jiangsu Province
- Jiangsu Province, P. R. China
- Youth Natural Science Foundation by China University of Mining and Technology [2008A030]
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Nonylphenol (NP) is a degradation product of nonylphenol polyethoxylates, which are widely used in the production of industrial and consumer surfactants. The aim of the present study was to evaluate the effect of NP on the antioxidant capacity and cognitive ability of mice. NP was given orally by gavages at doses of 0, 50, 100, and 200 mg kg(-1) d(-1) for 90 days. The results showed that NP significantly decreased the activity of superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) and at the same time increased malondialdehyde (MDA) levels in mice brains. Exploration, memory function and ability to learn a novel task were significantly decreased in NP fed mice. These results indicate that chronic high dose of NP exposure has the potential to generate oxidative stress and induce the cognitive impairment in male mice.
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