Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 11, Issue 3, Pages 967-981Publisher
MDPI AG
DOI: 10.3390/ijms11030967
Keywords
magnetic; nanoparticles; microglia; toxicity; uptake
Funding
- Biotechnology and Biological Sciences Research Council, UK
- US National Multiple Sclerosis Society
- BBSRC [BB/F013884/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F013884/1] Funding Source: researchfish
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Magnetic nanoparticles (MNPs) are important contrast agents used to monitor a range of neuropathological processes; microglial cells significantly contribute to MNP uptake in sites of pathology. Microglial activation occurs following most CNS pathologies but it is not known if such activation alters MNP uptake, intracellular processing and toxicity. We assessed these parameters in microglial cultures with and without experimental 'activation'. Microglia showed rapid and extensive MNP uptake under basal conditions with no changes found following activation; significant microglial toxicity was observed at higher particle concentrations. Based on our findings, we suggest that avid MNP uptake by endogenous CNS microglia could significantly limit uptake by other cellular subtypes in mixed neural cell populations.
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