Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 11, Issue 4, Pages 1808-1824Publisher
MDPI AG
DOI: 10.3390/ijms11041808
Keywords
apoptosis; Bcl-2; BH3-only; intrinsically disordered protein; protein structure
Funding
- Cancer Council Victoria [575549]
- Leukemia and Lymphoma Society [7015-02]
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Intrinsic cell death is mediated by interaction between pro-apoptotic and prosurvival proteins of the B-cell lymphoma-2 (Bcl-2) family. Members of this family are either intrinsically disordered or contain intrinsically disordered regions/domains that are critical to their function. Alternate splicing and post-translational modifications can determine the extent of these disordered regions and are critical for regulating Bcl-2 proteins. Conformational plasticity and structural transitions characterize the interactions within the Bcl-2 family, with conserved sequence motifs on both binding partners required for their molecular recognition.
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