Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 11, Issue 4, Pages 1557-1579Publisher
MDPI AG
DOI: 10.3390/ijms11041557
Keywords
DNA; nucleosome; chromatin; single molecule; magnetic tweezers; optical tweezers
Funding
- National Science Foundation [0504239]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0504239] Funding Source: National Science Foundation
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Genetic and epigenetic information in eukaryotic cells is carried on chromosomes, basically consisting of large compact supercoiled chromatin fibers. Micromanipulations have recently led to great advances in the knowledge of the complex mechanisms underlying the regulation of DNA transaction events by nucleosome and chromatin structural changes. Indeed, magnetic and optical tweezers have allowed opportunities to handle single nucleosomal particles or nucleosomal arrays and measure their response to forces and torques, mimicking the molecular constraints imposed in vivo by various molecular motors acting on the DNA. These challenging technical approaches provide us with deeper understanding of the way chromatin dynamically packages our genome and participates in the regulation of cellular metabolism.
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