Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 11, Issue 4, Pages 1458-1470Publisher
MDPI
DOI: 10.3390/ijms11041458
Keywords
antimicrobial peptide; titanium surface; MC3T3-E1 cells
Funding
- Japan Society for the Promotion of Science [20390499, 21390516]
- Japan Ministry of Economy, Trade and Industry
- Grants-in-Aid for Scientific Research [20390499, 21390516] Funding Source: KAKEN
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The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control-and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control-and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.
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