Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 10, Issue 1, Pages 366-384Publisher
MDPI
DOI: 10.3390/ijms10010366
Keywords
Human; brain bank; schizophrenia; alcohol; postmortem; molecular neuropathology; genome; proteome; receptor binding; clinical characterization
Funding
- The University of Sydney
- National Health and Medical Research Council of Australia
- Schizophrenia Research Institute
- National Institute of Alcohol Abuse and Alcoholism
- NSW Department of Health
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R24AA012725, R28AA012725] Funding Source: NIH RePORTER
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New developments in molecular neuropathology have evoked increased demands for postmortem human brain tissue. The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with best practice and quality control protocols. The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls. This review highlights changes in TRC operational procedures dictated by modern neuroscience, and provides examples of applications of modern molecular techniques to study the neuropathogenesis of many different brain disorders.
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