Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 9, Issue 11, Pages 2278-2289Publisher
MDPI
DOI: 10.3390/ijms9112278
Keywords
Polyethylenimine; 2-hydroxypropyl-alpha-cyclodextrin; non-viral gene delivery vector; co-polymer
Funding
- National High Technology Development Program of China [2007AA03Z355]
- National Nature Science Foundation of China [30571068]
- National Key Basic Research Program of China [2004CB518802]
- Foundation for the Author of a National Excellent Doctoral Dissertation [200364]
- Scientific Research Foundation of Guangdong Pharmaceutical University [43555025]
Ask authors/readers for more resources
A novel co-polymer based on 2-hydroxypropyl-alpha-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
