Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 33, Issue 6, Pages 1392-1400Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2014.1709
Keywords
thymus parasympathetic nerve; thymus sympathetic nerve; thymus innervation; thymus peptidergic nerve; thymus dopaminergic system
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The thymus is the primary site for T-cell lymphopoiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pathways occur, performing strict control on the maturation and selection processes of T lymphocytes. In this review, the main morphological characteristics of the thymus microenvironment, with particular emphasis on nerve fibers and neuropeptides were assessed, as both are responsible for neuro-immune-modulation functions. Among several neurotransmitters that affect thymus function, we highlight the dopaminergic system as only recently has its importance on thymus function and lymphocyte physiology come to light.
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