Journal
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
Volume 14, Issue 4, Pages 403-409Publisher
BEGELL HOUSE INC
DOI: 10.1615/IntJMedMushr.v14.i4.80
Keywords
medicinal mushrooms; antitumor activity; Auricularia auricula-judae; Ganoderma lucidum; Phellinus gilvus; Korean wild plants; doxorubicin
Funding
- Technology Development Program for Agriculture and Forestry, Ministry for Food, Agriculture, Forestry and Fisheries
- Kyungpook National University Research Fund
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The present study compares the antitumor activity of extracts from Auricularia auricula-judae, Phellinus gilvus, Ganoderma lucidum, and 100 Korean wild plants in the P388D1 macrophage cell line. The antitumor activity of A. auricula-judae extract (44.21%) did not differ significantly (P < 0.05) from those of Ph. Owls (39.46%) and G. lucidum (36.64%) at 1 mg/mL of concentration. Among 100 wild plants, Mortis bombycis f. kase, Draba nemorosa var. hebecarpa, Sedum oryzifolium, Lotus corniculatus var. japonicus, and Auricularia auricula-judae 70% ethanol extracts inhibited the viability of tumor cells by 41.85%, 37.31%, 30.29%, 31.98%, and 25.40% at 3 mg/mL of concentration, while inhibition concentration (IC50) values were 1.81, 1.49, 1.05, 1.10, and 0.72 mg/mL, respectively. In Sarcoma 180, NCI H358, and SNU 1 cell lines, the inhibitory activities of A. auricula-judae extract were 65.71%, 69.76%, and 68.01%, respectively. Taken together, the results obtained from the present study indicated that four plant extracts (4% of tested wild plants) and A. auricula-judae extract with similar levels of Ph. gilvus and G. lucidum extracts may be new potential antitumor agents.
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