Journal
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
Volume 13, Issue 1, Pages 1-6Publisher
BEGELL HOUSE INC
DOI: 10.1615/IntJMedMushr.v13.i1.10
Keywords
medicinal mushrooms; nitric oxide; mushroom extracts; macrophages; inducible NO synthase; NF-kappa B
Funding
- Guangzhou Science and Technology Project [2007Z3-E0421]
- Guangdong Province Science and Technology Project, P.R. China [2007A020300008-6]
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Nitric oxide (NO) is a gas with highly reactive radicals and is an important signal molecule in living organisms with diverse pathophysiological functions. Inducible NO synthase (iNOS) can be expressed in macrophages and is able to induce NO production. Studies have proposed that mushroom extracts can promote or inhibit NO production in macrophages through acting on iNOS, nuclear factor kappa B, and other signaling pathways. This article is dedicated to the mechanism of mushroom extracts affecting NO secretion in macrophages.
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