Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 308, Issue 8, Pages 1000-1008Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2018.08.008
Keywords
Small heat shock proteins; Immunomodulation; CD4(+) cells; CD8(+)cells; Tuberculosis; Mycobacterium indicus pranii; Th1 immune response
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Funding
- Centre of Excellence Grant from the Department of Biotechnology, Ministry of Science and Technology, Govt. of India [BT/PR12817/COE/34/23/2015]
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Utility of Mycobacterium indicus pranii (MIP) as a multistage vaccine against mycobacterial infections demands identification of its protective antigens. We explored antigenicity and immunogenicity of a candidate protein MIP_05962 that depicts homology to HSP18 of M. leprae and antigen' of Mycobacteriwn tuberculosis. This protein elicited substantial antibody response in immunized mice along with modulation of cellular immune response towards protective Thl type. Both CD4(+) and CD8(+) subsets from immunized mice produced hallmark protective cytokines,IFN-gamma, TNF-alpha and IL-2. This protein also enhanced the CD4(+) effector memory that could act as first line of defence during infections. These results point to MIP_05962 as a protective antigen that contributes, in conjunction with others, to the protective immunity of this live vaccine candidate.
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