Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 304, Issue 2, Pages 133-141Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2013.11.005
Keywords
Secretome; Protein secretion; Hypothetical proteins; Proteomics; Staphylococcus aureus
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Funding
- BMBF (Infektionsgenomik)
- DFG [GRK 840, SFB/TRR34, FOR 585]
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Secreted proteins constitute a reservoir of virulence factors. Here, an in silico analysis of the secretome of 15 S. aureus reference strains is presented revealing that about 30% of the encoded proteome of this bacterium could be secreted. In total 1354 proteins were predicted to be localized outside the cytoplasm representing the pan-secretome of S. aureus. 41% of these proteins have been identified to be expressed using different approaches. The function of at least 50% of the secreted proteins encoded by S. aureus is not yet clear and a possible role in virulence has to be elucidated. (c) 2013 Elsevier GmbH. All rights reserved.
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