Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 304, Issue 7, Pages 858-867Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2014.07.006
Keywords
Johne's disease; Paratuberculosis; Crohn's disease; Mycobacterium avium; Zoonosis
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Funding
- German Federal Ministry of Education and Research (BMBF) [ZooMAP 01K0750-5, ZooMAPII 01KI1003A-G]
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Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of paratuberculosis (Johne's disease [JD]), a chronic granulomatous enteritis in ruminants. JD is one of the most widespread bacterial diseases of domestic animals with significant economic impact. The histopathological picture of JD resembles that of Crohn's disease (CD), a human chronic inflammatory bowel disease of still unresolved aetiology. An aetiological relevance of MAP for CD has been proposed. This and the ambiguity of other published epidemiological findings raise the question whether MAP represents a zoonotic agent. In this review, we will discuss evidence that MAP has zoonotic capacity. (C) 2014 Elsevier GmbH. All rights reserved.
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