Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 303, Issue 8, Pages 674-677Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2013.09.010
Keywords
Tuberculosis; MIRU-VNTR; Microevolution
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Funding
- Fondo de Investigaciones Sanitarias (FIS) [S09/02205, P112/02080]
- PICATA predoctoral fellowship from the Moncloa Campus of International Excellence (UCM-UPM, Instituto de Investigacion Sanitaria Gregorio Maranon) [BE55/11]
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Clonal variants of Mycobacterium tuberculosis can emerge as a result of microevolution in a single host or after sequential infection of different hosts. The significance of subtle genotypic variations is still unknown. In three of the four loci analyzed from clonal variants differing in only one MIRU-VNTR locus, we found that the expression of the adjacent genes was modulated differently. These data highlight the potential advantages that acquisition of subtle variability may have in M. tuberculosis. (C) 2013 Elsevier GmbH. All rights reserved.
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