Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 300, Issue 8, Pages 549-556Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2010.08.007
Keywords
Pseudamonas aeruginosa; Anaerobic physiology; Antibiotic tolerance; Cystic fibrosis; Denitrification; Arginine fermentation; Pyruvate fermentation; NO-signaling; Universal stress protein
Categories
Funding
- Mukoviszidose e.V.
- Deutsche Forschungsgemeinschaft (DFG)
Ask authors/readers for more resources
During chronic infection of the cystic fibrosis (CF) lung, Pseudomonas aeruginosa grows and persists in a microaerobic to anaerobic environment. P. aeruginosa is well adapted to thrive under such conditions and contains multiple enzyme systems for energy generation under oxygen-restricted or even anaerobic conditions. Recent data confirm a heterogeneous environment in the CF lung and indicate that P. aeruginosa induces enzyme systems for microaerobic growth but also denitrification and fermentative pathways. Moreover, stress response systems as universal stress proteins enhance survival under anaerobic energy starvation conditions. Growth in these oxygen-limited environments induces a drastic physiological change in P. aeruginosa, like increased alginate production and alterations in the outer membrane, which contribute to an increased antibiotic tolerance. (C) 2010 Elsevier GmbH. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available