Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 300, Issue 2-3, Pages 142-147Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2009.08.017
Keywords
Alarmones; (p)ppGpp; Mechanisms of action; Synthesis pathways; Evolution
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Funding
- Deutsche Forschungsgemeinschaft [TR34]
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In most bacteria, nutrient limitations provoke the stringent control by the rapid synthesis of the alarmones pppGpp and ppGpp. The most prominent and highly conserved reaction is the repression of rRNA synthesis. Additionally, (p)ppGpp synthesis is also linked to many other physiological changes involving gene activation/repression but also protein translation, enzyme activation and replication. Whereas much of the basic research was performed with Escherichia coli there is now growing evidence that in gram-positive bacteria there are fundamental differences in (p)ppGpp synthesis, regulation and molecular function. Here we will focus on basic differences between firmicutes and proteobacteria, particularly E coli. (C) 2009 Elsevier GmbH. All rights reserved.
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