Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 298, Issue 3-4, Pages 279-290Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2007.05.002
Keywords
Borrelia burgdorferi; Borrelia spielmanii; Ixodes ricinus; ospA; ospC; dbpA; 16S rDNA; 5S-23S intergenic spacer
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In 475 Borrelia-infected Ixodes ricinus (2155 ticks investigated) from southern Germany the most common Borrelia buradorferi sensu lato species was B. garinii (34.3%) followed by A afzelii (25.1%), B. burgdorferi sensu stricto (22.0%), and B. valaisiana (12.7%).,B. spielmanii sp. nov. was detected in 5.9% of the 475 infected ticks. Hints for a focal distribution were found for B. spielmanii sp. nov. and B. garinii OspA type 4. In 242 patient isolates, dominance (66.9%) of B. afzelii for skin could be confirmed, while frequency of B. garinii in cerebrospinal fluid (CSF) isolates (51.1%) was comparable to the frequency in nymphal ticks (51.6%). Four patient isolates from southern Germany and two from Slovenia, all isolated from erythema migrans, could be assigned to B. spielmanii sp. nov. Within this new species high sequence identities were found for rrs,fla, and ospA while rrf-rrl, ospC, and dbpA were less conserved: three new ospC and two new dbpA sequence types were found. This genetic heterogeneity reveals that B. spielmanii sp. nov. did not evolve just recently. (c) 2007 Elsevier GmbH. All rights reserved.
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