Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 358, Issue -, Pages 25-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2013.11.002
Keywords
Collision-induced dissociation; QM/MM chemical dynamics; Glycosaminoglycans; Structural analysis; Fragmentation pattern; Charge-remote
Funding
- HPC resources of CCRT [2012082123, 2013082123]
- GENCI (Grand Equipement National de Calcul Intensif)
- Basic Science Program through the National Research Foundation of Korea (KRF)
- Ministry of Education, Science and Technology [2012-0002654]
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This work combines theoretical and experimental approaches to explore the fragmentation mechanisms occurring during the collision-induced dissociation (CID) of Galactose-6-Sulfate (Gal-6S). This compound is a building block of sulfated sugars and its study can shed light on fragmentation mechanisms occurring for other related systems. In particular, to understand in detail the fragmentation mechanisms at the molecular level, we have coupled mixed quantum/classical (QM + MM) direct chemical dynamics simulations with tandem mass spectrometry (MS/MS) experiments. Our results, on one hand, are in a good agreement with the charge-remote picture, which is usually proposed in the literature as fragmentation mechanism to account for the formation of many fragment ions. On the other hand, to reproduce some of the fragments ions obtained during our experiments, alternate dissociation pathways are proposed. (C) 2013 Elsevier B.V. All rights reserved.
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