Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 341, Issue -, Pages 34-44Publisher
ELSEVIER
DOI: 10.1016/j.ijms.2013.02.010
Keywords
Mass spectrometry imaging; Microscope mode; MCP; Pixelated detector; Timepix; MALDI; In-vacuum mounting; High voltage; Gigabit read-out; High m/z; Multiplexed TDC; High spatial resolution; Intact protein; Imaging mass spectrometry
Funding
- Dutch Technology Foundation STW, which is the applied science division of NWO
- Technology Programme of the Ministry of Economic Affairs [OTP 11956]
- Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO)
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The analytical capabilities of a Timepix detection system for mass spectrometry (imaging) are extended by the application of additional acceleration fields. Electrically biasing the detection system at a high potential delivers effective ion acceleration energies of 15/11 key for positive/negative ion mode matrix-assisted laser desorption ionization. This is comparable to the acceleration/extraction fields in commercially available time-of-flight mass spectrometers. This high voltage detector system enables measurements in both ion polarities and more sensitive analysis of higher molecular mass ions. The technical implementation of this system and first results in positive and negative ion mode are presented. The high voltage enhanced analytical capabilities of the Timepix detection system are demonstrated in the mass range up to 100 kDa. (C) 2013 Elsevier B.V. All rights reserved.
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