Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 310, Issue -, Pages 44-51Publisher
ELSEVIER
DOI: 10.1016/j.ijms.2011.11.005
Keywords
Pancreatic cancer; Metabolomics; Biomarkers; LCMS; Tissue extraction
Funding
- Proteomics and Metabolomics Shared Resource and the Tissue and Histopathology Shared Resource of Lombardi Comprehensive Cancer Center NIH [P30 CA5100]
Ask authors/readers for more resources
Pancreatic cancer (PC) is the fourth leading cause of cancer death in the United States, with 4% survival, 5 years after diagnosis. Patients with pancreatic cancer are usually diagnosed at late stages, when the disease is incurable. Sensitive and more specific markers are critical for supporting new prevention, diagnostic or therapeutic strategies. Here, we report mass spectrometry-based metabolomic profiling of human pancreas matched tumor and normal tissue. Multivariate data analysis using two independent methods shows significant alterations in the profiles of the tumor metabolome as compared to the normal tissue. These findings offer an information-rich matrix for discovering novel candidate biomarkers with diagnostic or prognostic potential. (C) 2011 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available