Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 306, Issue 2-3, Pages 114-122Publisher
ELSEVIER
DOI: 10.1016/j.ijms.2010.09.022
Keywords
3D ion trap; Monopolar DC; Ion injection
Funding
- National Institutes of Health [GM45372]
- Jonathan Amy Facility for Chemical Instrumentation
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The effects of the application of various DC magnitudes and polarities to an end-cap of a 3D quadrupole ion trap throughout a mass spectrometry experiment were investigated. Application of a monopolar DC field was achieved by applying a DC potential to the exit end-cap electrode, while maintaining the entrance end-cap electrode at ground potential. Control over the monopolar DC magnitude and polarity during time periods associated with ion accumulation, mass analysis, ion isolation, ion/ion reaction, and ion activation can have various desirable effects. Included amongst these are increased ion capture efficiency, increased ion ejection efficiency during mass analysis, effective isolation of ions using lower AC resonance ejection amplitudes, improved temporal control of the overlap of oppositely charged ion populations, and the performance of broad-band collision induced dissociation (CID). These results suggest general means to improve the performance of the 3D ion trap in a variety of mass spectrometry and tandem mass spectrometry experiments. (C) 2010 Elsevier B.V. All rights reserved.
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