Journal
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
Volume 303, Issue 2-3, Pages 129-136Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2011.01.021
Keywords
Nucleotide; Mononucleotide; Photodissociation; Fragmentation
Funding
- National Science Foundation through the JILA Atomic, Molecular and Optical Physics Frontier Center [PHY-0551010, CHE-0845618]
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Irradiation of nucleotides in the gas phase with ultraviolet light can lead to their fragmentation. We present a comparison of UV photofragmentation data on ribo-, deoxyribo- and cyclic nucleotides with guanine and adenine as nucleobases. The envelope of the UV photofragment spectra does not depend significantly on the detailed structure of the sugar-phosphate backbone. The fragment channels observed in the photofragmentation of ribonucleotides are very similar to those of deoxyribonucleotides with small differences in the relative abundances of the product ions. In fragmentation of cyclic nucleotides, the deprotonated base anions are the most abundant fragments, in contrast to the non-cyclic nucleotides, where this channel is significantly weaker. We discuss the abundances in the context of possible fragmentation mechanisms and structural differences of the parent molecules. (C) 2011 Elsevier B.V. All rights reserved.
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