Journal
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
Volume 126, Issue 6, Pages 953-956Publisher
SPRINGER
DOI: 10.1007/s00414-012-0750-2
Keywords
Isotretinoin; Adverse drug reaction; Muscle pain; Rhabdomyolysis; Myocytolysis
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Isotretinoin is considered to be a safe and effective therapy in otherwise therapy-resistant acne. Elevated serum creatine phosphokinase values with or without muscle-related symptoms in isotretinoin-treated patients have been reported and interpreted as benign phenomena, lethal cases have not been described yet. We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.
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