Journal
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Volume 30, Issue 2, Pages 167-172Publisher
WILEY
DOI: 10.1111/j.1751-553X.2007.00929.x
Keywords
thalassemia; cancer; seminoma; non-Hodgkin lymphoma; Hodgkin disease
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Thalassemia represents the world's most common monogenic disease, characterized by absence of or decreased globin chain production. The lifespan of thalassemia patients has been extended as a result of current supportive treatment. We report three cases of cancer (non-Hodgkin lymphoma, Hodgkin disease, and seminoma) in thalassemic patients. Factors that may contribute to the pathogenesis of cancer seem to be infections and iron overload through mechanisms of oxidative damage; immunomodulation or coexistence of the two diseases may only be coincidental.
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