Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 14, Issue 6, Pages E460-E468Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2009.06.028
Keywords
Innate immunity; Polymorphism; Fungi; Infection; Susceptibility
Categories
Funding
- Specific Targeted Research Project 'MANASP' [LSHE-CT-2006, 037899 (FP6)]
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Fungi are a major threat in immunocompromised patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop fungal diseases. The traditional view of immune suppression as a key risk factor for susceptibility to fungal infections needs to be accommodated within new conceptual advances on host immunity and its relationship to fungal disease. The critical role of the immune system emphasizes the contribution of host genetic polymorphisms to fungal disease susceptibility. This review highlights the present knowledge on innate immunity genetics that associates with susceptibility to fungal diseases. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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